Question

Write the location and function of the sertoli cells in humans.

Answer 1

These cells are present in the male reproductive organ and can contribute to the production of sperm in the spermatogenesis.

Complete answer:
Sertoli cells are the seminiferous tubules epithelial supporting cells. They emerge from the epithelial sex cords of the gonads. They are large simple columnar cells that extend from the membrane of the basement to the lumen. They circle and distinguish the proliferation of germ cells around which they create pockets and provide nutrients and phagocytose the abundant spermatid cytoplasm which is not necessary in sperm formation. They are linked by continuous close junctions that screen the tubule into two compartments: the basal and the adluminal. The basal and adluminal compartments cannot transfer large molecules.
A sertoli cell is a "nurse" cell of the testis, which is located in the seminiferous tubule and contributes to the production of sperm in the spermatogenesis process.
The function of sertoli cells in the human body are given below.
1. Human sertoli cells (HSerC) are important for the creation of the blood test barrier's growth and spermatogenesis.
2. HSerC restricts the movement to the adluminal compartment with seminiferous tubules with materials such as hormones and nutrients.
3. In addition to the protection of blood samples, HSerC also provides the seminiferous tubules the key structural protection and defends the germ cells against the immune response.
4. Proliferation of Aberrant HSerC can lead to male reproductive disorders like testicular germ cell cancer, cryptorchidism, hypospadia and low-sperm numbers.
5. The proliferation of HSerC is partly regulated by follicle-stimulating hormone (FSH) and thyroid hormone (TH) where FSH is propelling and TH promoting further relaxation.
6. Cultured HSerC is a valuable in vitro model for recognizing and managing male reproductive disorders better.

Note: Sertoli is a "nurse" cell of the testis, which forms part of a seminiferous tubule and contributes to the production of sperm in the spermatogenesis. The adenohypophysis stimulates the FSH and it has an FSH receptor on its membranes. It is found precisely in the seminiferous tubules. Sertoli cell formation is regulated by a factor protein testis.