Question

Wobble hypothesis deals with
A.Phenomena of multiple codons coding for the code of single amino acid
B.Phenomena of multiple codons coding for the code for a different amino acid
C.Phenomena of anticodon coding for the code for a different amino acid
D.None of these

Answer 1

Codon is a sequence of three nucleotides which together form a unit of genetic code in DNA or RNA molecules. Genetic code describes the relationship between the sequence of DNA bases such as Adenine, Cytosine, Guanine, Thymine in a gene.

Complete answer:
The Wobble hypothesis proposes that normal base pairing can occur between nitrogen bases in positions 1 and 2 of codon and the corresponding bases 3 and 2 in the anticodon.
Genetic code is the set of rules used by cells to translate information encoded within genetic material such as DNA or RNA sequences of nucleotide triplets or codons into proteins.
Amino acids are organic compounds that contain amine (NH2) and carboxyl (COOH) functional groups with side chains specific to amino acid. The amino acids are classified into three groups:
1.Essential amino acids
2.Non-essential amino acids
3.Conditional amino acids
The nine essential amino acids are histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine. Amino acids function as the building blocks of proteins. Proteins are required in catalysing the chemical reactions in the cell.
The Wobble hypothesis deals with the phenomenon of degeneracy seen in the genetic code through tRNA recognition of more than one codon. mRNA consists of four bases and codons are made up of three bases. Possible 64 codon configurations exist and thus there will be 64 tRNA and 64 amino acids are associated. As 21 amino acids exist which means some tRNA must bind multiple codons and give the same amino acid for different codon configuration.

Hence the correct answer is option(A)

Note: Another 3 codons that represent an amino acid are start codons. The three letter nature of codons means four nucleotides present in mRNA- A, U, G, C which gives different combinations.