Question
Chemistry Question on cell potentials
Which one or more of the following statements is/are correct regarding the transport and retention of proteins in different cell organelles?
Mannose 6-phosphate residues are involved in targeting proteins to lysosomes.
Transport of proteins into the mitochondrial compartment is aided by positively charged amino acid residues at the N-terminus and internal hydrophobic segments.
The retention of protein in the ER lumen requires the KDEL sequence motif at the C-terminus.
Nuclear proteins are transported in an unfolded conformation and the nuclear localization signal sequence is subsequently cleaved by peptidases in the nucleoplasm
Mannose 6-phosphate residues are involved in targeting proteins to lysosomes.
Solution
The correct options are: (A):Mannose 6-phosphate residues are involved in targeting proteins to lysosomes.(B):Transport of proteins into the mitochondrial compartment is aided by positively charged amino acid residues at the N-terminus and internal hydrophobic segments. (C):The retention of protein in the ER lumen requires the KDEL sequence motif at the C-terminus..