Question

Which one of the following reactions is an example of oxidative decarboxylation?

• A. Conversion of succinate to fumerate
• B. Conversion of fumerate to malate
• C. Conversion of pyruvate to acetyl CoA
• D. Conversion of citrate to isocitrate

Answer 1

Answer: (C)

Conversion of pyruvate to acetyl CoA

Answer 2

Oxidative decarboxylation is the link reaction or gateway step as it links glycolysis with Krebs? cycle. Pyruvate which is formed in cytoplasm by glycolysis produce $CO_2, NADH_2$ and acetyl CoA by oxidative decarboxylation reaction. Acetyl CoA functions as substrate entrant for Krebs? cycle.