Question
Pharmaceutical Chemistry Question on Different classes of therapeutic drugs
Which of the following statement/s are correct regarding the alkylating agents as anticancer agents:
A. They get converted into highly nucleophilic anions and bind to the nitrogen atom of guanine intercalating the DNA strands
B. Cyclophosphamide and busulfan belong to this class
C. They inhibit the DNA synthesis by inhibiting the DNA polymerase enzyme
D. They inhibit the DNA supercoiling by irreversibly inhibiting the DNA topoisomerase enzyme
Choose the correct answer from the options given below:
A
A, B and D only are correct
B
Only B is correct
C
Only A and B are correct
D
All A, B, C and D are correct
Answer
Only B is correct
Explanation
Solution
The correct option is (B): Only B is correct