Question

Which of the following most appropriately describes haemophilia?
A. Recessive gene disorder
B. X – linked recessive gene disorder
C. Chromosomal disorder
D. Dominant gene disorder

Answer 1

It is a blood coagulation issue which demonstrates cross-heritage in those characters from father to daughter and from mother to son is passed on.

Complete answer:
Haemophilia is a largely inherited genetic disease that detracts from the ability of the body to make blood clots. This leads to bleeding, quick bruising and a growing risk of fluidity inside articulations or the brain for a long time after an injury. Those suffering from a mild case of disease can only experience symptoms after an accident or operation. Bleeding may lead to permanent injury, while bleeding in the brain can lead to long-lasting headaches, seizures or a decline in consciousness.

Haemophilia A results in low concentrations of coagulation factor VIII and haemophilia B, which results due to low coagulation factor IX, are two major forms of haemophilia. They usually come from one parent via an X chromosome that carries a nonfunctional gene. Hemophilia A is about one in five thousand to ten thousand, while haemophilia B is about one in forty thousand, males at birth. As both haemophilia A and B are X-linked recessive conditions, women rarely suffer significantly. Any women with a nonfunctional gene can be moderately symptomatic with either of the X chromosomes.

Thus, the correct answer is option ‘B’. i.e., X – linked recessive gene disorder.

Note: Haemophilia is an inherited blood condition that does not correctly coagulate blood. It is caused if there is insufficient coagulation factor in blood. A blood protein that controls bleeding is a coagulation factor. Bleeding typically is internal. A large variety of bleeding events occurs in the joints or muscles due to the low levels of coagulation. This can occur spontaneously without any apparent cause or as a consequence of trauma or injury.