Question

Which of the following is the least likely to be involved in stabilizing the three-dimensional folding of most proteins?
A. Hydrophobic interaction
B. Ester bonds
C. Hydrogen bonds
D. Electrostatic interaction

Answer 1

To stabilize three-dimensional folding of proteins means when it is to bring the amino acids that are located far apart in the polypeptide sequence together within the completely folded structure of a protein.

Complete answer:
Option A- Hydrophobic interaction- Hydrophobic Interaction is an important process that is used for the folding of proteins. This is required and very essential or important in keeping a protein stable and biologically active, as it allows the protein to decrease in surface and is reduced to the undesirable interactions with water.
Option B- Easter bonds- Ester bonds are basically the covalent bonds that are least likely to be involved in stabilizing the three dimensional folding of most proteins. The reason for that is they are formed in nucleic acids and lipids, but not proteins. ester is a chemical compound that is derived from an acid.
Option C- Hydrogen bonds- Hydrogen bonding grants rigidity to the protein structure and specificity to intermolecular interactions. Hydrogen bonds usually form between the sidechain of one segment and the side chains of other segments. This kind of bonding helps in stabilizing the protein, especially when it occurs on the surface of the protein.
Option D- Electrostatic interaction- Electrostatic interactions are the weak ones that usually stabilize the tertiary structure of proteins. They play a key role in deciding the structure, stability, binding affinity, and chemical properties, and so even the biological reactivity, of proteins and nucleic acids.

The correct option is B, Easter Bonds as they are covalent bonds and least expected to be found there.

Note:
Different kinds of weak interactions hold the interacting segments together in the form of protein. Hydrophobic interaction is where the H bonds and electrostatic interactions are the weak ones and stabilize the tertiary structure of proteins.