Question

Which of the following is not a part of the inflammatory responses?
A) Antibodies
B) Swelling
C) Redness
D) Presence of Histamine.

Answer 1

Innate immunity refers to the defense mechanism against the foreign particles mediated by small chemical messengers along with phagocytic cells, whereas Humoral immunity refers to the defense mechanism against the intruders mediated by antibodies.

Complete answer:
Inflammatory response is a major mechanism of innate immunity which is mediated by several chemical messengers, inflammatory response refers to the changes in the part of pathogen activity. Swelling, redness are the physiological changes seen as a part of inflammatory response. Histamines are small chemical components which act as messenger molecules to initiate inflammatory response. Therefore, Option A is the correct answer. Therefore antibodies are not a part of inflammatory response as they are involved in humoral immunity. They tag the pathogen cells and make them susceptible to phagocytosis.

Additional Information: Tissue damage or any microbial infection induces a complex pathway collectively called as inflammatory response. There are major carnival signs that reflect inflammatory responses. VASODILATION: an increase in the diameter of the blood vessels of the nearby capillaries occurs as the vessels that carry blood away from the affected area constrict, forming engorgement of capillary network. These networks are responsible for the tissue redness called erythema and an increase in the tissue temperature. This later results in the SWELLING of the affected tissue. Presence of Histamines is also one of the signs of inflammatory response, it's a chemical released by Mast cells and also by other varieties of cells. HISTAMINE binds to receptors on the nearby capillaries and venules causes vasodilation and increases permeability of phagocytic cells.

Hence the correct answer is option ‘A’.

Note: Inflammatory response is a major mode of self defence in case of innate immunity. Antibodies act as mediators in case of type 1 hypersensitivity reaction but not in inflammatory response.