Question

Which of the following inhibits protein synthesis by binding to $50\,S$ ribosome?

• A. Tetracyclin
• B. Streptomycin
• C. Erythromycin
• D. Penicillin

Answer 1

Answer: (C)

Erythromycin

Answer 2

Erythromycin antibiotic is synthesised by Streptomyces erythraeus. It is usually bacteriostatic and binds with the $23 \,S \, rRNA$ of the $50\,S$ ribosomal subunit to inhibit peptide chain elongation during protein synthesis. Erythromycin is a relatively broad-spectrum antibiotic it is effective against Gram-positive bacteria mycoplasmas and a few Gram-negative bacteria.