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Question: Which is the correct reaction: (a) \(Pyruvic\quad acid\quad +\quad NAD^{ + }\quad +\quad Co-A\quad...

Which is the correct reaction:
(a) Pyruvicacid+NAD++Co−A→Mg++PyruvatedehydrogenaseAcetylCo−A+NAD⋅H++CO2Pyruvic\quad acid\quad +\quad NAD^{ + }\quad +\quad Co-A\quad \xrightarrow [ Mg^{ ++ } ]{ Pyruvatedehydrogenase } Acetyl\quad Co-A+NAD\cdot H^{ + }+CO_{ 2 }

(b) Pyruvicacid+FAD++Co−A→Mg++PyruvatedehydrogenaseAcetylCo−A+FAD⋅H++CO2Pyruvic\quad acid\quad +\quad FAD^{ + }\quad +\quad Co-A\quad \xrightarrow [ Mg^{ ++ } ]{ Pyruvatedehydrogenase } Acetyl\quad Co-A+FAD\cdot H^{ + }+CO_{ 2 }

(c) Pyruvicacid+NADP++Co−A→Mg++PyruvatedehydrogenaseAcetylCo−A+NADP⋅H++CO2Pyruvic\quad acid\quad +\quad NADP^{ + }\quad +\quad Co-A\quad \xrightarrow [ Mg^{ ++ } ]{ Pyruvatedehydrogenase } Acetyl\quad Co-A+NADP\cdot H^{ + }+CO_{ 2 }

(d) Pyruvicacid+NAD++Co−A→Mg++PyruvatedehydrogenaseAcetylCo−A+NAD⋅H+Pyruvic\quad acid\quad +\quad NAD^{ + }\quad +\quad Co-A\quad \xrightarrow [ Mg^{ ++ } ]{ Pyruvatedehydrogenase } Acetyl\quad Co-A+NAD\cdot H^{ + }

Explanation

Solution

Formation of Acetyl Co-A is important as it enters the Krebs cycle for the acetylation of Oxaloacetic acid. Formation of Acetyl Co-A requires several coenzymes.

Complete answer:
Pyruvate which is formed by the glycolytic catabolism of carbohydrates in the cytosol, after it enters the mitochondrial matrix undergoes oxidative decarboxylation by a complex set of the reactions catalyzed by pyruvate dehydrogenase. It requires several coenzymes like NAD+ and Coenzyme A.

The reaction is:
Pyruvicacid+NAD++Co−A→Mg++PyruvatedehydrogenaseAcetylCo−A+NAD⋅H++CO2Pyruvic\quad acid\quad +\quad NAD^{ + }\quad +\quad Co-A\quad \xrightarrow [ Mg^{ ++ } ]{ Pyruvatedehydrogenase } Acetyl\quad Co-A+NAD\cdot H^{ + }+CO_{ 2 }
Two molecules of pyruvic acid formed from one glucose molecule during glycolysis undergo the formation of two molecules of Acetyl CoA, CO2{ CO }_{ 2 } and 2NADH+2H+. This reaction is called the Link Reaction of aerobic respiration.
So, the answer is, ‘Pyruvicacid+NAD++Co−A→Mg++PyruvatedehydrogenaseAcetylCo−A+NAD⋅H++CO2Pyruvic\quad acid\quad +\quad NAD^{ + }\quad +\quad Co-A\quad \xrightarrow [ Mg^{ ++ } ]{ Pyruvatedehydrogenase } Acetyl\quad Co-A+NAD\cdot H^{ + }+CO_{ 2 }.’

Note: -For aerobic respiration to take place within mitochondria the pyruvic acid formed during glycolysis is transported from the cytoplasm into the mitochondria.
- The complete oxidation of pyruvate occurs in two steps, Formation of Acetyl CoA and TCA cycle.
-The TCA cycle occurs in the inner mitochondrial matrix. The NADH2NADH_2 molecule formed in the process enters the ETS of the mitochondria to release energy.
-The link reaction is also known as Transition Reaction or gateway Reaction.