Question
Chemistry Question on Amines
Which compound will give Hoffmann bromamide a degradation reaction?
A
Ar-CONH2
B
Ar-NH2
C
Ar-NO2
D
Ar-CH2-NH2
Answer
Ar-CH2-NH2
Explanation
Solution
The correct answer is option (D): Ar-CH2-NH2
The Hoffman bromamide degradation reaction is used to convert amides to primary amines. The amide will be treated with bromine in the presence of a base (NaOH) to produce a primary amine. RCONH₂ +Br₂+ 4NaOH → RNH₂ +Na₂CO₃ +2NaBr +2 H₂O , Ar-CH₂-NH₂ Will undergo Hoffman bromamide degradation and form the corresponding primary amine (RNH₂)