Solveeit Logo
Login

Question

Question: Where are albumin, fibrinogen and prothrombin made?...

Where are albumin, fibrinogen and prothrombin made?

Explanation

Solution

Plasma proteins include albumin, globulins, and fibrinogen. The plasma proteins, particularly albumin, sustain colloid osmotic (oncotic) pressure (COP), which is required to maintain intravascular volume. Adult horses have a COP value of 15–22 mmHg. Albumin and globulins are the two types of proteins found in blood. Blood proteins aid in the production of molecules that your body requires to function.

Complete answer:
The liver produces albumin, fibrinogen, and prothrombin.
Albumin is a blood plasma protein made in the liver that accounts for a major part of all plasma proteins.

Fibrinogen is produced by the hepatocytes in the liver.

Prothrombin is generated in the liver and undergoes co-translational modification, which changes 10 glutamic acids on prothrombin to gamma carboxy glutamic acid in a vitamin K-dependent mechanism.

Prothrombin is a blood component that aids in blood coagulation. The liver produces the majority of it. During blood clotting, prothrombin in blood plasma is transformed to thrombin in the presence of thromboplastin and calcium ions. The liver produces albumin, which is a globular protein. It is the most prevalent blood protein in mammals and can be found in blood plasma. Albumin serves as a carrier protein for steroid, fatty acid, and thyroid hormones in the blood and contributes to oncotic pressure, which helps to maintain extracellular fluid content.

Fibrinogens are big, soluble, complex glycoproteins found in vertebrates that aid in blood clotting. It is produced by hepatocytes in the liver. Thrombin converts the fibrinogen molecule into fibrin during the development of a blood clot.
As a result, the right response is 'Liver'.

Note:
The liver produces fibrinogen, which is then released into the bloodstream along with many other clotting factors (also called coagulation factors). When a body tissue or blood vessel wall is wounded, hemostasis kicks in to assist stop the bleeding by producing a plug at the injury site.