Question

What product is formed when NH reacts with $\alpha$-ketoglutaric acid

• A. Glutamate
• B. Fumarate
• C. Pyruvate
• D. Glutamine

Answer 1

Answer: (A)

Glutamate

Answer 2

In biosynthesis of amino acids, inorganic ammonium nitrogen is incorporated to organic acid to form amino acid glutamate. In reductive deamination, ammonium ion combine directly with carboxylic acid (e.g., intermediate of Krebs??cycle, $\alpha$-ketoglutaric acid). The reaction is catalysed by enzyme glutamate dehydrogenase and $NADPH + H^{+}$ acts as hydrogen donor