Question
Pathophysiology Question on Classification of infectious diseases
What is the proposed mechanism of action of artemisinin in the treatment of malaria:
A
Inhibition of dihydrofolate reductase, interfering with folate synthesis
B
Blocking of the Plasmodium falciparum ATPase, disrupting ion homeostasis
C
Generation of reactive oxygen species (ROS) by cleavage of the endoperoxide bridge, leading to parasite death
D
Inhibition of the heme polymerase enzyme, causing accumulation of toxic heme
Answer
Generation of reactive oxygen species (ROS) by cleavage of the endoperoxide bridge, leading to parasite death
Explanation
Solution
The correct option is (C): Generation of reactive oxygen species (ROS) by cleavage of the endoperoxide bridge, leading to parasite death .