Solveeit Logo
Login

Question

Question: What is in the \(5'\) UTR?...

What is in the 5′5' UTR?

Explanation

Solution

The 5′5' untranslated region is known as leader sequence. The leader sequence is a region of mRNA which directly codes for initiation codon. The 5′5' untranslated region is important for the regulation of translation process as- the transcript has different mechanisms in viruses, prokaryotes and eukaryotes. The untranslated regions have points for ribosomes during translation.

Complete answer-
5′5' untranslated region serves as the initiation point for the ribosome synthesis and can elaborate RNA secondary and tertiary structures and also translate a cap-dependent or cap-independent manner. RNA structures in 5′5' untranslated region example- RNA G- quadruplexes, may serve as steric blocks for scanning ribosomes and the eukaryotic initiation factor.
5′5' untranslated region recruits the ribosome entry sites to 5′5' UTRs in a cap-independent manner. Some are required in regular physiological conditions and tend to integrate with RNA chaperons reading open frames and G-quadruplex structures for function.
The initiation factor has a specialized function in translating directly or chemically modified 5′5' UTRs in mRNA to selective internal initiation. In vivo RNA structure proving technologies use chemical modifiers to assess the RNA structure inside cells.
Single-nucleotide resolution chemical RNA structure is to explore the state of folding to the transcriptome in living cells. The models for 5′5' untranslated region impact the translation validated by compensatory mutagenesis.

Note:
RNA molecules can fold intricate shapes and provide control to the gene expression beyond the sequence. The current mechanic structures of 5′5' untranslated region have methodologies to explore them. These structures have cap-dependent translation through helicase mediated RNA structures and internal ribosome entry sites.