Question

What is chemical ionization mass-spectrometry (Cl-MS)?

Answer 1

The mass-to-charge ratio of ions is measured using mass spectrometry (MS), an analytical method. A mass range, or a plot of intensity as a function of mass-to-charge ratio, is a common way to view the data. Mass spectrometry is used in a variety of areas and can be used on both pure samples and complex mixtures.

Complete step by step answer:
We need to know that in mass spectrometry, chemical ionization (CI) is a soft ionization process. Burnaby Munson and Frank H. Field were the first to propose this in $1966$. This method belongs to the field of gaseous ion-molecule chemistry. Electron ionization is used to ionize reagent gas molecules, which then react with analyte molecules in the gas phase to achieve ionization. Few typical variants of this technique include negative chemical ionization (NCI), charge-exchange chemical ionization (CECI), and atmospheric-pressure chemical ionization (APCI). Identification, structure elucidation, and quantitation of organic compounds are all important applications of CI. Chemical ionization's use is not limited to analytical chemistry; it also has uses in physiological, biological, and medicinal fields.

Additional information: The ion signal is plotted as a function of the mass-to-charge ratio in a mass spectrum. These spectra are used to figure out a sample's elemental or isotopic signature, particle and molecule weights, and the chemical identity or arrangement of molecules and other chemical compounds.

Note: It must be noted that the versatility of CIMS stems in part from the fact that a wide range of reagent gases and, thus, reagent ions can be used to ionize the analyte; in many cases, the reagent mechanism can be adapted to the problem at hand. Molecular mass estimation, structure elucidation, and diagnosis and quantification are all problems that can be solved using CI methods.