Question
Pharmacology Question on Chemotherapy
Vinca alkaloids that are used in combination therapy to treat a variety of tumors. How to cancer cells normally gain resistance to these agents
A
Mutation of the target structure
B
Overexpression of the carrier protein called P-glycoprotein
C
Increased metabolism of the drug
D
Decreased ability of the drug to enter target cells
Answer
Overexpression of the carrier protein called P-glycoprotein
Explanation
Solution
The correct option is (B) :Overexpression of the carrier protein called P-glycoprotein