Question
Biopharmaceutics and Pharmacokinetics Question on Bio-availability & Bio-equivalence
Under which of the following conditions in-vitro-in-vivo correlation for a drug fails?
A
When the drug’s absorption takes place by a complex
B
When the dissolution medium is adequately simulated
C
When the drug is highly soluble
D
When the drug is highly permeable but poorly soluble
Answer
When the drug is highly soluble
Explanation
Solution
The correct option is (C): When the drug is highly soluble