Question

The reason for “drug induced poisoning” is:
(A) Binding at the allosteric sites of the enzyme
(B) Binding irreversibly to the active site of the enzyme
(C) Binding reversibly at the active site of the enzyme
(D) Bringing conformational change in the binding site of the enzyme

Answer 1

As we know that reversibility represents the interchange of groups and repeat for the time. But irreversible processes happen only once, therefore; when drugs are taken in a large dose or on a regular basis it causes health issues.

Complete step-by-step answer: Drug poisoning is also known as drug overdose. When drugs are used over a long period of time, they cause side-effects.
For example- If we use Aspirin (which is an analgesic) over a long period of time, then it causes bleeding due to change in our body.
The reason behind is that when the drug is regularly taken in our body, Allosteric sites of the enzymes are those sites where the modulator binds. Due to this binding, the active sites are deformed. Hence, the active sites of the enzymes are blocked.

Therefore, the correct option is option (A).

Note: The modulators bind other than active sites irreversibly. This causes permanent blockage of the active sites of the enzymes.