Question

The protein required for coagulation of blood is
A.Haemoglobin
B.Globulin
C.Fibrinogen
D.Albumin

Answer 1

Blood coagulation is the process of turning substances circulating in the blood into an insoluble gel. The gel plug will penetrate the blood vessels and prevent blood loss. This process requires clotting factors, calcium, and phospholipids. Clotting factors (proteins) are produced by the liver.

Complete answer: The coagulation mechanism involves the presence of calcium and other coagulation factors, and factor X activates an enzyme called prothrombin activator. The enzyme prothrombin activator then converts the plasma protein prothrombin to thrombin. Thrombin is an enzyme that converts fibrinogen into fibrin. Polymeric fibrin forms a clot with platelets at the wound site. Therefore, the protein required for blood coagulation is fibrinogen. It is a plasma protein produced in the liver and present in the circulating blood.
The normal value of fibrinogen is between 200 and 400 milligrams per decilitre. A fibrinogen value below 50 milligrams per decilitre may mean you are at risk of bleeding after surgery. A fibrinogen value of more than 700 milligrams per decilitre may mean you are in danger of forming a blood clot, which may damage your heart or brain.
Thus the option (C) Fibrinogen, is correct.

Note: Aspirin can reduce the formation of thrombin, which in turn affects the production of fibrin. According to researchers, it may also affect acetylated fibrinogen, leading to increased clot permeability and lysis. Fibrin and fibrinogen degradation products (FDP) tests are commonly used to diagnose disseminated intravascular coagulation (DIC).