Question
Chemistry Question on reaction mechanism
The most reactive to nucleophilic attack at the carbonyl group is
A
B
C
D
Answer
Explanation
Solution
The case with which a nucleophile attacks the carbonyl group depends upon the electron deficiency, i.e. the magnitude of positive charge on carbonyl group carbon. Since, among all the groups attached
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has maximum electron withdrawing effect, electron deficiency will be maximum at carbonyl carbon of acetyl chloride. Hence, acetyl chloride, i.e.
is most reactive to nucleophilic attack at carbonyl group