Question
Pharmaceutical Chemistry Question on Different classes of therapeutic drugs
The fluoroquinolones act by:
A
Inhibiting folic acid synthesis, reducing nucleotide production and DNA synthesis
B
Inhibiting DNA gyrase and topoisomerase IV, causing supercoiling and fragmentation of bacterial DNA
C
Disrupting peptidoglycan cross-linking, weakening the bacterial cell wall
D
Inhibiting ribosomal subunits, leading to the cessation of protein synthesis
Answer
Inhibiting DNA gyrase and topoisomerase IV, causing supercoiling and fragmentation of bacterial DNA
Explanation
Solution
The correct option is (B): Inhibiting DNA gyrase and topoisomerase IV, causing supercoiling and fragmentation of bacterial DNA.