Question

The enzymes hexokinase which catalyses glucose to glucose-6- phosphate in glycolysis is inhibited by glucose-6-phosphate. This is an example of

• A. competitive inhibition
• B. non-competitive inhibition
• C. feedback allosteric inhibition
• D. positive feedback.

Answer 1

Answer: (C)

feedback allosteric inhibition

Answer 2

Competitive inhibition is the reversible inhibition of enzyme activity due to presence of substrate analogues. Non competitive inhibition is the reduction of enzyme activity by a factor that has no real structural similarity with the substrate. Allosteric inhibition is reversible noncompetitive inhibition occurring in case of allosteric enzymes. Herein, the inhibitors are the products or intermediates of reactions are catalyzed by the enzymes. Hence, it is also called end product inhibition or feedback inhibition.