Question

The central dogma of protein synthesis in kinetoplastid is
A) G-RNA →DNA →mRNA →protein
B) DNA →G-RNA →mRNA →protein
C) DNA →DNA →mRNA →protein
D) mRNA →G-RNA →DNA →protein

Answer 1

In this question we are going to find the correct option for the given question. Let us know about a little bit of the central dogma of protein synthesis. The central dogma of molecular theory describes the two-step process. One is transcription and other is translation, which the information in genes flows into proteins.

Complete answer:
Let's discuss protein synthesis in kinetoplastid to find the correct answer.
From DNA to RNA to protein, the central dogma is a framework to describe the flow of genetic information The mitochondrial DNA of the kinetoplastids has many open reading frames.Sequences from which RNA- is synthesized which is later translated to protein by protein synthesis. These open reading frames unlike the open reading frames of the regular nuclear genes are incomplete.So, though they can be transcribed to form an mRNA (specifically pre-edited mRNA) for it to be translated to a protein more modifications to the mRNA are needed (editing of mRNA).These modifications are brought about by the use of another RNA molecule called the Guide RNA (G-RNA).When the editing is done, then the mature mRNA is finally translated to protein. Hence option A, option C, and option D are incorrect.

Thus, the correct answer is option ‘B’ :DNA →G-RNA →mRNA →protein

Note: The importance of central dogma is that,

It is the basic framework of how genetic information is transferred from a DNA sequence to a protein product inside a cell.
It suggests that the DNA contains all the information which is required to make all our proteins.
RNA is the messenger which helps in carrying this information to the ribosomes.