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Biology Question on Principles of Inheritance and Variation

Sickle cell anaemia is due to

A

Change of Amino Acid in α-chain of Haemoglobin

B

Change of Amino Acid in β-chain of Haemoglobin

C

Change of Amino acid in both α and β chain of Haemoglobin

D

Change of Amino acid either α or β chain of Haemoglobin

Answer

Change of Amino Acid in β-chain of Haemoglobin

Explanation

Solution

In sickle cell anemia, there is a mutation in the beta (β)-globin chain of hemoglobin, which results in the substitution of one amino acid (glutamic acid) with another (valine), leading to the formation of abnormal hemoglobin known as hemoglobin S (HbS). This alteration in the β-globin chain leads to the characteristic sickle-shaped red blood cells and the associated health problems seen in individuals with this condition. So, the correct option is (B): Change of Amino Acid in β-chain of Haemoglobin