Question

Sickle cell anaemia is

• A. autosomal dominant inheritance
• B. X-linked recessive inheritance
• C. autosomal recessive inheritance
• D. X-linked dominant inheritance

Answer 1

Answer: (C)

autosomal recessive inheritance

Answer 2

Sickle cell anaemia is an autosomal recessive hereditary disease due to $Hb^{S}$ (mutated) instead of $Hb^{A}$ (normal) gene and $\beta$ -chain of haemobin has amino acid valine, instead of glutamic acid in $6^{th}$ position. The erythrocytes sickle shaped.