Question

Select the correct combination of statements regarding Myasthenia gravis
i. It is an autoimmune disorder.
ii. It causes insufficient acetylcholine binding that affects muscular contraction.
iii. Antibodies are developed against acetylcholine.
iv. Antibodies are developed against acetylcholine receptors
v. Antibodies are developed against acetylcholine esterase
vi. It causes drooping of eyes
A. (i),(ii),(iv),(vi)
B. (i),(iii),(v),(vi)
C. (i),(ii),(iv),(vi)
D. (ii),(iii),(iv),(v)

Answer 1

Myasthenia gravis which is an autoimmune neuromuscular disease that’s congenital that leads to muscle weakness. In addition to this antibodies have an effect on one's nerves and hamper the flexibility to get muscular contractions.

Complete answer:
Myasthenia gravis (MG) is caused by the failure of contractor transmission mediated by antibodies. Myasthenia gravis is associated with neural diseases within which the Ach receptor gets broken. It is caused by the circulation of antibodies that block neurotransmitter receptors at the postsynaptic myoneural junction inhibiting the excitant effects of neurotransmitter and nicotinic receptors at contractor junctions. The 1st noticeable symptom is the weakening of the muscles resulting in drooping of eyelids.
-The first statement says it is an autoimmune disease which is correct since myasthenia gravis is a neuromuscular disease.
-The second statement is also right since the receptors bind to acetylcholine affecting the muscular contraction ultimately leading to problems like muscle weakness.
-The third statement states that antibodies are developed against acetylcholine which is wrong since the antibodies which block the acetylcholine receptors are at postsynaptic neuromuscular junction which in turn inhibit the excitatory effects of acetylcholine at the neuromuscular junction site making the fourth statement correct.
-The fifth statement is wrong since acetylcholinesterase is used to treat myasthenia gravis.
-The first noticeable symptom of MG is drooping of eyes which causes weakness of eye muscle.

Hence, Statements (i) (ii), (iv) and (vi) are correct.

Note: Myasthenia gravis affects both genders and is seen to occur across all racial and ethnic groups. It most typically impacts young adult ladies (under 40) and older men (over 60), however, it will occur at any age, be it at childhood. The disease of the neuromuscular junction isn't hereditary neither is it contagious. Sometimes, the sickness could occur in addition to one member of the family.