Question
Question: Friedel-Craft's acetylation of chlorobenzene gives ______ as the major product....
Friedel-Craft's acetylation of chlorobenzene gives ______ as the major product.
A
3-chloroacetophenone
B
2-chloroacetophenone
C
1-(4-chlorophenyl)ethanone
D
1-(3-chlorophenyl)ethanal
Answer
1-(4-chlorophenyl)ethanone
Explanation
Solution
In Friedel-Crafts acetylation, the acylium ion (CH₃CO⁺) is the electrophile. Although chlorine is deactivating, it is ortho/para directing. Steric factors favor substitution at the para-position. Thus, the major product is 1-(4-chlorophenyl)ethanone.