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Question

Biopharmaceutics and Pharmacokinetics Question on Bio-availability & Bio-equivalence

Match List I with List IIList IList II
AWhen two dosage forms have equal t maxIWhen their total body clearance is constant.
BAUC values of the two analogs can be compared to measure relative bioavailabilityIIAbsorption rate constants are equal
CUrinary data is valid to measure bioavailability. III. WIIIWhen fraction absorbed and elimination rate is constant.
DC max is proportional to the rate of absorptionIVExcretion of drug and/or metabolite is related to the bioavailable dose.

Choose the correct answer from the options given below:

A

A ‐ II, B ‐I , C ‐IV‐ , D ‐ III

B

A ‐I , B ‐II , C ‐III , D ‐IV

C

A ‐I, B ‐IV, C ‐III, D ‐II

D

A ‐III , B ‐I , C ‐II , D ‐IV

Answer

A ‐ II, B ‐I , C ‐IV‐ , D ‐ III

Explanation

Solution

The correct option is (A): A ‐ II, B ‐I , C ‐IV‐ , D ‐ III