Question

Lactic acid accumulation leads to
A) Muscle fatigue
B) Kidney fatigue
C) Liver fatigue
D) All of these

Answer 1

Lactic acidosis is a type of metabolic acidosis that starts when a person overproduces or undergoes lactic acid and his or her body can not adapt to these changes.

Complete answer:
People with lactic acidosis have problems with the ability to remove excess acid from their body from their liver(and sometimes their kidneys). Acidity levels in body fluids , such as blood, spike if lactic acid builds up in the body more quickly than it can be removed.This acid buildup causes a pH level imbalance in the body, which should always be slightly alkaline rather than acidic.

The body's metabolism is relatively high during strenuous exercise, which requires an enormous supply of energy. Muscles move from aerobic metabolism, which requires oxygen, to anaerobic metabolism, which does not, to maintain a steady supply of energy. In order to provide energy, muscles can anaerobically break down carbohydrates, resulting in a compound called pyruvate.

Pyruvate can be further aerobically broken down to provide more energy when oxygen is available. But pyruvate is converted into lactic acid when enough oxygen is not available. Lactic acid, resulting in the release of hydrogen ions, is rapidly broken down into a compound called lactate. The body is able to clear lactate by metabolising it for energy, but it accumulates in the muscles and bloodstream when lactate production exceeds the clearance rate.

While rising lactate levels are linked to tired muscles, fatigue is not actually caused by lactate. Rather, it is the increased acidity in the tissues that contributes to the sensation of fatigue due to the buildup of hydrogen ions. Accumulation of lactic acid does not lead to fatigue in the kidneys or to liver fatigue.

Thus the correct answer is option (A) Muscle fatigue.

Note: Lactic acid build-up happens when the muscles don't have enough oxygen to break down glucose and glycogen. This is called the metabolism of anaerobes.Two kinds of lactic acid are available: L-lactate and D-lactate. Too much L-lactate causes most forms of lactic acidosis.