Question

Is ANP a diuretic?

Answer 1

Atrial natriuretic peptide (ANP), brain (or B-type) natriuretic peptide (BNP), and C-type natriuretic peptide (CNP) are the three physiologically active peptides in the natriuretic peptide family (CNP). ANP and BNP, for example, are cardiac hormones released by the heart.

Complete answer:
The first hormone isolated from the heart as a powerful natriuretic/diuretic and hypotensive agent was atrial natriuretic peptide (ANP). ANP features an intramolecular ring structure with two cysteine residues connecting it, as well as N- and C-terminal extensions. Mammals, amphibians, and bony fishes all have ANP, while birds, reptiles, cartilaginous fishes, and cyclostomes don't.

Atrial natriuretic hormone, or ANP, belongs to a group of peptides that play a key role in blood pressure regulation, most notably through their ability to increase water and sodium excretion in the kidney. The majority of ANP is made and produced by cardiac muscle cells, especially those in the atria. The hormone was given its name because of its source (atrial), principal physiologic impact (natriuresis, or sodium excretion), and peptide nature. ANP is an anti-hypertensive hormone that plays a key function in blood pressure management.

As the prohormone preproANP, ANP is first produced within cardiac myocytes. The physiologically active peptide ANP is released via proteolytic cleavages and is 28 amino acids long in humans, with a loop formed by a disulfide connection between two cysteines. Low quantities of ANP are generated in a variety of different organs, and considerable synthesis occurs in the ventricles of the heart in some pathologic situations (e.g. heart failure).

Yes, ANP is a diuretic hormone, ANP also inhibits sodium reabsorption by the renal tubules, lowering blood pressure and decreasing water reabsorption (acting as a diuretic). Atrial natriuretic hormone, or ANP, belongs to a group of peptides that play a key role in blood pressure regulation, most notably through their ability to increase water and sodium excretion in the kidney. The majority of ANP is made and produced by cardiac muscle cells, especially those in the atria.

Note: BNP (brain natriuretic peptide) is a peptide hormone that is released in response to cardiac myocyte volume expansion and increased wall stress. BNP aids in the promotion of diuresis, natriuresis, systemic and pulmonary vasodilation, and the lowering of circulating endothelin and aldosterone levels.