Question
Physical Pharmacy Question on Solubility
Indicate which of the following statements is true
A
A weakly acidic drug is unionised when pH of the solution is at last 2 pH units below its pKa
B
Acidic drugs are noninonized at pH 9
C
Acidic drugs are less soluble in alkaline solution
D
The higher the pKaof a weak acid, the stronger is acid
Answer
A weakly acidic drug is unionised when pH of the solution is at last 2 pH units below its pKa
Explanation
Solution
The correct option is (A) : A weakly acidic drug is unionised when pH of the solution is at last 2 pH units below its pKa