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Question: If a nucleotide lacking a hydroxyl group at the 3’ end is added to a PCR, what would be the outcome?...

If a nucleotide lacking a hydroxyl group at the 3’ end is added to a PCR, what would be the outcome?

A

No additional nucleotides would be added to a growing strand containing that nucleotide.

B

Strand elongation would proceed as normal.

C

Nucleotides would only be added at the 5’ end.

D

T. aquaticus DNA polymerase would be denatured.

Answer

No additional nucleotides would be added to a growing strand containing that nucleotide.