Question
Pharmacy Question on Structure of DNA and RNA
Identify the false statement
A
Hard electrophiles have a formal positive charge at the electrophilic centre (e.g. carbocations).
B
The softest biological nucleophilic sites are cysteine thiol groups on proteins.
C
Primary and secondary amino groups of lysine and histidine on the proteins are hard nucleophiles.
D
Softest nucleophiles are the oxygen atoms of purines and pyrimidines on DNA and RNA.
Answer
Softest nucleophiles are the oxygen atoms of purines and pyrimidines on DNA and RNA.
Explanation
Solution
The correct option is(D): Softest nucleophiles are the oxygen atoms of purines and pyrimidines on DNA and RNA.