Question

How does rough endoplasmic reticulum differ from smooth endoplasmic reticulum?

Answer 1

The endoplasmic reticulum (ER) is a continuous membrane system that forms a series of flattened sacs within the eukaryotic cell cytoplasm and serves multiple functions like synthesis, folding, alteration and transport of proteins.

Complete answer:

Rough Endoplasmic Reticulum	Smooth Endoplasmic Reticulum
The membrane surface of RER has ribosomes.	The membrane surface of SER does not have ribosomes.
Cisternae and a few tubules form them.	Vesicles and tubules form them.
It is involved in synthesis of proteins and enzymes.	It is involved in synthesis of cholesterol, lipids. Steroids and glycogen.
It helps in formation of lysosomes.	It is responsible for giving rise to spherosomes.
It has narrow pores. Synthesized polypeptides move through them into ER channels.	Pores are absent.
It is associated with the nuclear envelope.	It is associated with plasma lemma.
It is internal.	It is peripheral.
It has ribophorins.	Ribophorins are absent.
It might develop from a nuclear envelope.	It might develop from RER.

Note: 1.SER is involved in detoxification of drugs, metabolic waste and enzymes.
2.SER also helps in carbohydrate metabolism and synthesis of new membranes.
3.RER does synthesis and transport of proteins.