Question

How do cytokines affect the humoral immune response?

Answer 1

Cytokines are small glycoproteins formed by a variety of types of cells, primarily leukocytes that regulate immunity, haematopoiesis and inflammation. Innate immunity, acquired immunity and a plethora of inflammatory responses are controlled by them. IL-I, IFN and nerve growth factors were the initial findings.

Complete answer:
Humorous immune responses are those mediated by secreted antibodies that, by default, are immunoglobulins. Also, the only cell type that can generate antibodies is B cells. The B cells undergo maturation, proliferation and differentiation upon interaction with TH2 cells and under the influence of interleukins 4 and 5.
They differentiate into plasma cells that generate and secrete antibodies and long-lived Memory B cells, quiescent B cells that can be mobilized when the antibody is required in the future.
Such cytokines can cause 'class switching' as well. The B cells begin to express IgM and then IgM+IgD. Class switching helps the B cells to generate other immunoglobulin classes, such as IgG, IgE, and IgA.
Many other cytokines are available that either directly act on B cells or control T helper cells. The production rate and form of antibody produced are indirectly influenced by this.
By activating the 'complement mechanism' and labelling phagocytosis pathogens, all coordinated by cytokines, the antibodies then help remove pathogens.

Note:
Cytokines function through receptors and are particularly important in the immune system; cytokines modulate the balance between immune responses that are humoral and cellular. Innate and humoral immunity are very difficult to see as separate mechanisms because they have so much interplay between them.