Question
Biopharmaceutics and Pharmacokinetics Question on Bio-availability & Bio-equivalence
Grape fruit juice is P- glycoprotein and CYP40 enzyme inhibitor. if drug X is degraded by proteolytic enzymes, administration of grapefruit juice with X
A
Increase bioavailability of X
B
Decrease Bioavailability of X
C
Does not affect bioavailability of X
D
Cause unexpected action of X
Answer
Decrease Bioavailability of X
Explanation
Solution
The correct option is (B) : Decrease Bioavailability of X