Question

Glucose-$6$-P dehydrogenase deficiency is associated with haemolysis of:
A. Lymphocytes
B. RBCs
C. Platelets
D. Leucocytes

Answer 1

Glucose-$6$-P dehydrogenase ($G6PD$) insufficiency is a genetic disease caused by a structural flaw in $G6PD$, a "housekeeping" enzyme that is critical for blood cell survival and capacity to adapt to oxidative stress. The affected blood cells are hemolyzed as a result of this deficit. It is an example of a recessive genetic disorder.

Complete answer:
Option: A –$G6PD$deficiency leads to hemolytic anemia thus, lymphocytes are not hemolyzed.
So, Option A is not correct.
Option: B – $G6PD$ dehydrogenase deficiency leads to hemolytic anemia i.e. RBCs are hemolyzed due to their inability to work properly in $G6PD$ deficiency.
So, Option B is correct.
Option: C – Platelets are not hemolyzed in $G6PD$ deficiency.
So, Option C is not correct.
Option: D – Leukocytes are not hemolyzed in $G6PD$ dehydrogenase deficiency.
So, Option D is not correct.

Therefore, Option B. RBCs is the correct answer

Additional information:
Hemolytic anaemia, which happens when red blood cells are destroyed faster than the body can replenish them, is the most frequent medical issue linked with $G6PD$ deficiency. Paleness, jaundice (yellowing of the skin and whites of the eyes), black urine, tiredness, shortness of breath, an enlarged spleen, and a fast heart rate are all symptoms of this form of anaemia. Skin ulcers are uncommon, yet they can happen to anybody.

Note:
$G6PD$ deficiency is inherited in an X-linked recessive manner, and symptoms are more frequent in men. This is due to the fact that males only have one copy of the $G6PD$ gene. They will surely have $G6PD$ insufficiency if this one copy contains a mutation. Despite the fact that females have two copies of the $G6PD$ gene, some girls are impacted just as badly as males.