Question
Pharmaceutical Analysis Question on Non-aqueous titrations
For very weak acidic drugs, with pKa >8.
A
They are unionized at all pH, hence absorption is rapid and independent of GI pH
B
They are affected by changes in pH, hence absorption is pH dependent
C
They are ionized in the entire pH range of GIT, hence poorly absorbed from GIT
D
They are ionized in the gastric pH, hence better absorbed from the stomach
Answer
They are unionized at all pH, hence absorption is rapid and independent of GI pH
Explanation
Solution
The correct option is (A): They are unionized at all pH, hence absorption is rapid and independent of GI pH