Question

Due to non-disjunction of chromosomes during spermatogenesis, sperm carry both sex chromosomes (22A + XY) and some sperms do not carry sex chromosomes (22A + 0). If these sperms fertilize normal eggs (22A + X). What types of genetic disorders appear among the offspring?
A: Down’s syndrome and Turner’s syn
B: Down’s syndrome and Cri-du-chat-synd
C: Turner’s syndrome and Klinefelter’s syndrom
D: Down’s syndrome and Klinefelter’s syndrome

Answer 1

Turner syndrome (X monosomy) (45, X0). Klinefelter syndrome is a sex chromosome aneuploidy in humans (47, XXY). Down syndrome has an extra copy of chromosome 21 and Cri-du-chat-syndrome is caused by the deletion of genetic material on the p arm of chromosome 5.

Complete answer: Fusion of sperm "22+ 0" and normal egg "22+X" will give rise to female children with chromosome composition "44+X". The Absence of one X-chromosome causes Turner's Syndrome as 44 +XO. Symptoms of turner’s syndrome include puberty delay, rudimentary ovaries, heart defects, infertility, short stature. They may not menstruate. Turner syndrome is the monosomy where the affected individual is monosomic for the X chromosome. The fusion of sperm with "22+ XY" and normal egg "22+X" will give rise to a male child with chromosome composition "44+XXY". The presence of one extra copy of the X-chromosome in males causes Klinefelter's syndrome. The affected individual has 44+ XXY chromosomes. Some symptoms of Klinefelter are less facial and body hair, low sex drive, low testosterone level, and less muscle tone and growth. Klinefelter syndrome is a Sex chromosome aneuploidy caused by nondisjunction of chromosomes during meiosis resulting in one extra X chromosome and in some cases it may have multiple additional sex chromosomes. Turner syndrome is the monosomy where the affected individual is monosomic for the X chromosome. Cri-du-chat-syndrome is a genetic condition that is caused by the deletion of genetic material on the p arm (small arm) of chromosome 5. Down syndrome is a genetic disorder caused by abnormal cell division that results in an extra copy of chromosome 21 (Trisomy syndrome).

Hence, the correct option is (c).

Note: In humans there are 23 pairs of chromosomes, in which 22 pairs are numbered chromosomes called autosomes and one pair is of sex chromosome, X and Y. Child get half of their chromosomes from mother and a half from father.