Question
Biology Question on the molecular basis of inheritance
Discontinuous synthesis of DNA occurs in one strand, because
DNA molecule being synthesised is very long
DNA dependent DNA polymearse catalyses polymerisation only in one direction (5′→3′)
it is a more efficient process
DNA ligase has to have a role
DNA dependent DNA polymearse catalyses polymerisation only in one direction (5′→3′)
Solution
The DNA-dependent DNA polymerases catalyse polymerisation only in the one direction, that is 5′→3′. This creates some additional complications at the replicating fork. Consequently, on one strand (the template with polarity 3′→5′), the replication is continuous, while on the other (the template with polarity 5′→3′), it is discontinuous. The discontinuously synthesised fragments are later joined by the enzyme DNA ligase.