Question

Decreased levels of estrogen is a common cause for

• A. myasthenia gravis
• B. tetany
• C. osteoporosis
• D. gout

Answer 1

Answer: (C)

osteoporosis

Answer 2

Osteoporosis is a disease characterised by low bone mass and loss of bone tissue that may lead to weak and fragile bones. Osteoporosis occurs when there is an
imbalance between new bone formation and old bone resorption. The body may fail to form enough new bone, or too much old bone may be reabsorbed, or both. Generalised osteoporosis is common in elderly people and in women following menopause. In osteoporosis, the osteoblastic (bone forming) activity in the bone usually is less than normal and consequently the rate of bone deposition is depressed. Estrogens inhibit osteoclastic (bone resorption) activity in the bones and therefore stimulate bone growth. After menopause, almost no estrogens are secreted by ovaries. This estrogen deficiency leads to increased osteoclastic activity in the bones, decreased bone matrix and decreased deposition of bone calcium and phosphate. In some women, these effects result in osteoporosis.