Question
Biopharmaceutics and Pharmacokinetics Question on Bio-availability & Bio-equivalence
Decrease in effective surface area available to the dissolution medium leading to a fall in the dissolution rate, may happen due to which one of the following reasons?
A
Addition of cyclodextrin
B
Addition of surfactant to increase the surface tension
C
Addition of hydrophilic diluent
D
Surface charges due to extreme particle size reduction
Answer
Surface charges due to extreme particle size reduction
Explanation
Solution
The correct option is (D): Surface charges due to extreme particle size reduction