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Question

Biopharmaceutics and Pharmacokinetics Question on Bio-availability & Bio-equivalence

Decrease in effective surface area available to the dissolution medium leading to a fall in the dissolution rate, may happen due to which one of the following reasons?

A

Addition of cyclodextrin

B

Addition of surfactant to increase the surface tension

C

Addition of hydrophilic diluent

D

Surface charges due to extreme particle size reduction

Answer

Surface charges due to extreme particle size reduction

Explanation

Solution

The correct option is (D): Surface charges due to extreme particle size reduction