Question

Cyclosporin A, an immunosuppressive drug is produced by
A.Aspergillus niger
B.Monascus purpureus
C.Penicillium notatum
D.Trichoderma polysporum

Answer 1

Immunosuppression is the reduction of immune activity of the body. Immunosuppressive drugs help in decreasing the activity of the immune system.

Complete step by step answer:
Instead of tissue matching, blood group matching patients are given immunosuppressive drugs, so that their own immune system does not attack the grafted part. Our body is able to differentiate between the self and nonself part hence there is always risk of rejection of grafted parts by the receiver body in transplantation. In our body some cell also work as immune suppressors like suppressor T-cells. These cells suppress the activity of cytotoxic and helper T-cells so that the immune system does not attack the owner's body. But there are some drugs that we use as immunosuppressants like Cyclosporine A. Cyclosporin A is a good immune suppressor. Cyclosporin destroys T cell immune response. This drug prevents rejection of kidney, heart and liver transplant. Cyclosporine A is produced by fungi Trichoderma polysporum. Trichoderma polysporum produces Cyclosporine with the help of fermentation process. Cyclosporine can be taken by mouth and through injection. Tacrolimus, Sirolimus, Prednisone are examples of other immunosuppressive drugs.

So the correct option is (D).

Additional Informational:
Chromosome 6 code the pair of alleles that complex are responsible for recognition of lymphocyte and antigen presentation, they are called major histocompatibility (MHC). It is also known as Human Leukocyte Antigen(HLA).

Note:
Cyclosporine is a group of amino acids. Only Cyclosporine used clinically is Cyclosporin A. Cyclosporin A was the first immunosuppression that showed less side effects. For the treatment of autoimmune disease we also use immunosuppression.