Question

At what pH does pepsin work best?

Answer 1

We know that pepsin is an endopeptidase enzyme that degrades proteins into peptides. It is formed in the chief cells of the stomach lining and is one of the most important digestive enzymes in humans and many other animals' digestive systems, where it aids in the digestion of proteins.

Complete answer:
As we know that digestion starts inside the mouth. At the point when we bite the food, it's mixed in with saliva, which supplies dampness as well as the carbohydrate digestion enzyme, amylase. When we eat crude food, its proteins work with the salivary amylase to start digestion. The stomach plays a critical role within the early stages of food digestion. Asides from crushing and stirring the food bolus, it additionally secretes a blend of mixes, aggregately alluded to as "gastric juice." Digestive juice contains water, bodily fluid, acid, pepsin, and factor of those five segments, pepsin is the essential enzyme associated with protein absorption. It separates proteins into more modest peptides and amino acids which will be handily retained inside the digestive system. Particular cells inside the gastric lining alluded to as chief cells, discharge pepsin in an inactive form, or zymogen structure, called pepsinogen.
Pepsin relies upon an acidic climate for protein digestion. Protein digestion continues to require place throughout the tiny intestines via the consequences of pancreatic enzymes: trypsin, chymotrypsin, elastase, and carboxypeptidase. As such, pepsin isn't essential for all times, and protein digestion can still happen within the absence of pepsin. It’s worth mentioning that pepsin remains structurally stable until a minimum of a pH. Pepsin is a proteolytic enzyme secreted by the chief cells of gastric glands as a proenzyme pepsinogen. It is activated by gastric hydrochloric acid.
Therefore, The optimal pH for pepsin is $1.8,$ which is highly acidic.

Note:
Remember that the Pepsin is an endopeptidase enzyme that degrades proteins into peptides. It is formed in the chief cells of the stomach lining and is one of the most important digestive enzymes in humans and many other animals' digestive systems, where it aids in the digestion of proteins.