Question

Alzheimer disease in humans is associated with the deficiency of
A. Acetylcholine
B. Serotonin
C. Amyloid oligosaccharides
D. Glutamic acid

Answer 1

Alzheimer disease is a progressive degenerative disease of the brain which is caused by the accumulation of amyloid protein plaques inside the neurons resulting in their degeneration. The disease is believed to be caused by two defective alleles, one on chromosome 21 and other on chromosome 19.

Complete answer: Alzheimer is the most common form of dementia. Dementia can be described as the decline in behavioral, thinking and social skills of a person. This occurs due to decrease in the concentration of acetylcholine in the cells. Acetylcholine is a neurotransmitter that performs an important role in memory and learning functions. The early symptoms of the disorders are forgetting small details, recent events and conversations. Eventually the person suffering from the disorder also loses the ability to carry out everyday tasks and is left with severe impairment.
The changes in the brain lead to an increasing problem in memory, making judgements and decisions, thinking and reasoning, planning and performing familiar tasks, changes in personality and behavior. Such persons require special attention and care from their friends, family and neighbors.
Glutamic acid is associated with the sickle cell anaemia disorder. Sickle cell anaemia is a genetic disorder in which the afflicted individuals contain red blood cells which under low oxygen tension becomes elongated and curved.
Alzheimer disease in humans is associated with the deficiency of acetylcholine.
So, the correct answer is “Option A”.

Note: The disease Alzheimer is non-curable. As the disease advances, the affected person loses brain functions, is dehydrated, malnourished and suffers from other infections which eventually leads to his death.