Question

After the immunofluorescence technique done on stomach sections, Antibodies found in parietal cells are a marker for?
A. Thyrotoxicosis
B. Pernicious Anaemia
C. Iron deficiency Anaemia
D. Thalassemia

Answer 1

Immunofluorescence is a technique that can be used on tissue sections, cultured cells, or individual cells that are rebuilt by a variety of methods. Antibodies can be utilized in this method to analyse the number of proteins, glycoproteins, and other antigen targets including biological and non-biological molecules. The antibody acknowledges the target molecule and binds with them.

Complete answer:
● Antibodies to gastric parietal cells are related to autoimmune gastritis and pernicious anaemia.
● The parietal cell release characteristic component, which is crucial for the absorption of vitamin
B12 which is necessary for erythropoiesis.
● The devastation of parietal cells by the immunofluorescence method promotes a failure for
retaining vitamin B12 and therefore leads to anaemia.
● Antibodies against gastric parietal cell antigens are diagnostic of persistent autoimmune gastritis
whether ensuing in pernicious anaemia or not.
● Parietal cell antibodies are autoantibodies, proteins generated by the immune system that
erroneously focuses on a sort of specific cell that lined the stomach wall.
● This test recognizes these antibodies in the blood to help analyse pernicious anaemia.
● Iron deficiency anaemia is also called as ferropenic that evolves when the level of iron in the
body is dropped extremely low to support normal RBC production.
● Insufficient dietary iron, undermined iron absorption, bleeding, or loss of iron in the urine may
be the cause of iron deficiency anaemia.
● Thalassemia is defined as an inherited blood disease that affects the body to have less
haemoglobin than normal.
● Thyrotoxicosis is defined by the clinical indications of inappropriately high thyroid hormone
activity in tissues.
So, the correct answer is option B.

Note: The parietal cell of the stomach secretes hydrochloric acid. The fundamental factor of thyrotoxicosis is hyperthyroidism, which is an overactivity of the thyroid gland bringing about surplus levels of overactivity. The deficiency of vitamin B12 can also cause anaemia.