Question

Addisons disease results from :

• A. hypertrophy of gonads
• B. hypo-secretion of adrenal cortex
• C. hyperactivity of cells of Leydig
• D. none of the above

Answer 1

Answer: (B)

hypo-secretion of adrenal cortex

Answer 2

Addison's disease is an endocrine disorder, that manifests as primary adrenal insufficiency, which involves pathology in the adrenal glands. The condition develops as a result of bilateral adrenal cortex destruction. Damage to the adrenal cortex results in decreased production of adrenocortical hormones, with inadequate cortisol, aldosterone, and adrenal androgen produced. Autoimmune factors are responsible for the destruction of the adrenal glands in most cases, but infection (such as tuberculosis) hemorrhage, adrenal vein thrombosis, and carcinoma are also known to be the cause of a significant number of cases.