Question

ADA deficiency can be cured by

• A. Heart Transplantation
• B. Bone-marrow Transplantation
• C. Liver Transplantation
• D. Kidney Transplantation

Answer 1

Answer: (B)

Bone-marrow Transplantation

Answer 2

Bone marrow transplantation, also known as hematopoietic stem cell transplantation, is the primary curative treatment for ADA deficiency.
The procedure involves replacing the patient's faulty bone marrow cells with healthy stem cells from a compatible donor. The transplanted stem cells, which contain the functional ADA gene, can produce normal ADA enzyme activity and restore immune function in the patient.

The reason bone marrow transplantation is effective in treating ADA deficiency is that bone marrow is the site of hematopoiesis, where blood cells, including immune cells, are produced. By replacing the defective bone marrow cells with healthy ones, the patient receives a source of functional ADA enzyme, which helps in the proper development and functioning of immune cells.