Question
Pharmacology Question on Cardiovascular system
A patient on lithium therapy developed hypertension. He was started on Thiazide for hypertension. After a few days, he developed coarse tremors and other symptoms suggestive of lithium toxicity. What is the probable mechanism of interaction?
A
Thiazide increases the tubular reabsorption of lithium
B
Thiazide inhibits the metabolism of lithium
C
Thiazides act as an add on the drug to lithium
D
All of the above
Answer
Thiazide increases the tubular reabsorption of lithium
Explanation
Solution
The correct option is (A): Thiazide increases the tubular reabsorption of lithium.